An Introduction to Medicinal Chemistry, 4Ed

• Publisher:   Oxford University Press, USA
• Number Of Pages:   752
• Publication Date:   2009-03-25
• ISBN-10 / ASIN:   0199234477
• ISBN-13 / EAN:   9780199234479

The average person in the UK will take more than 14,000 pills over the course of their life, yet few people consider the long road of development that has made that drug work without being toxic. An Introduction to Medicinal Chemistry presents the field in an engaging style that is very accessible to students.
Medicinal chemistry is a fast-moving field whose continuous new developments have far-reaching implications for world health. As such, this text presents a complete course in medicinal chemistry, from first principles of drug action, to design and development, to specific drugs from HIV inhibitors to painkillers.
The book builds on the history of drug development, but does not assume much background knowledge. The focus is on building upon the understandings of the molecular function of drugs, and from there, taking a broad overview of the topical issues and most frequently used techniques.
An Introduction to Medicinal Chemistry remains a leading text for the growing number of medicinal chemistry courses internationally, especially as modules in medical chemistry become a more popular option on chemistry courses. With enhanced attention to the pedagogical details such as key points and boxes, as well as having specific case studies highlighted in distinct sections, Patrick's new edition enables a full understanding of the subject and a clear idea of where the field is heading.

The book was recieved in great condition. Timing was amazing and there was great contact between the buyer (myself) and the seller.

This text has a very good chapters on QSAR (quantitative-structure activity relationship). I recommend this for the beginning scholars and students interested in QSAR for drug design.

This book is good in the sense that it is an easy read for anyone interested in the subject. The drawings and cartoons provide a bit of humor to the text and the writing is cloear and focused. The only drawback to the book is that the layperson does not get the full effect of the book without a very good grasp of biochemistry (hence the term layperson!). To get the real scope of the book, one would need to read a good Biochem text ( I personally suggest Lehninger, et. al. Principles of Biochemistry, 3rd ed.). A good pharmacological text would greatly enhance the reader's understanding of the subject as well (i.e. Goodman and Gilman's). Otherwise, the book does give a very brief, very good overview of many aspects of Medicinal Chemistry.

The author states that this book is aimed at undergraduates who have a basic grounding in chemistry and are interested in a future career in the pharmaceutical industry. Chemistry background includes now elements of quantum chemistry and molecular orbital theory. The author completely fails in including these elements in the Chapter on Quantitative Structure-Activity Relationships. Moreover, he seems completely unaware of the fundamental contributions of Quantum Chemistry to QSAR. This text could perfectly include elements of (INTRODUCTORY) quantum-chemical applications to QSAR (the scientific literature is full). We must wait until the next edition to get a book that can be recommended to serious students!. Juan S. Gomez-Jeria Associate Professor Faculty of Sciences University of Chile.

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